Sand and water control are main technical strategies for high-efficiency horizontal wells development in loose sandstone oil and gas reservoirs. But, lack of awareness of solid (sand) and fluid (oil, gas and water) inflow profile into wells limits the effect of sand and water control in horizontal wells. In fact, the initial properties of formation or reservoir is of obviously heterogeneous. Sands and fluid are produced from formation with a certain micro synergetic mechanism, which is still not well known. The inflow profile of solid and fluid tend to be also heterogeneous and evolve dynamically with time and space. Generally, lack of deep knowledge of the inflow profile dynamic evolution and the resultant tactics of separated sand-water controlling are the key technical bottlenecks for horizontal wells development. Aiming at the above problems, the research project will focus on the synergetic time-space evolution mechanism and dynamic simulation of solid-fluid inflow profile of horizontal wells in heterogeneous sandstone reservoirs. The detailed study contents involve micro synergetic coordination mechanism of sand-fluid production, the mechanism of affecting law of long-term solid-fluid removal on reservoir properties, and the visual and dynamic simulation of solid-fluid production profile evolution, with final investigation of the application method in systematic sand-water control in long-interval horizontal wells. The objective of the study is to develop an integrated model to simulate the dynamic changing process of solid-fluid inflow profile and the corresponding software package, which can provide key and strong supports for sand-water control, well completion and production optimization